BIOSTIMULATORS

Advanced
technology

Tissue biostimulators (Skinboosters) are technologically advanced preparations or substances that have a positive effect on the skin. Nevertheless, creating a precise and accurate definition for all of them is difficult because they differ in composition, mechanism of action, technique of administration and application.

Tissue stimulators can be divided into:

  • those administered with mesotherapy and deep mesotherapy,
  • those served in a similar fashion to hyaluronic acid fillers,
  • those provided in designated points recommended by the manufacturer.

Types of
treatments:

biostymulatory_czb
  1. Hyaluronic acid without cross-linking agents (Profhilo)
  2. Atelocollagen (Linerase)
  3. Amino acid complexes (Sunekos, Jalupro)
  4. Sodium succinate (Xela rederm)
  5. Calcium Hydroxyapatite (Radiesse, Crystalis)
  6. Polycaprolactone (Ellanse, Miracle)
  7. Nucleotides (Nucleophile, Lumi eyes)

Types of
treatments:

biostymulatory_czb
  1. Hyaluronic acid without cross-linking agents (Profhilo)
  2. Atelocollagen (Linerase)
  3. Amino acid complexes (Sunekos, Jalupro)
  4. Sodium succinate (Xela rederm)
  5. Calcium Hydroxyapatite (Radiesse, Crystalis)
  6. Polycaprolactone (Ellanse, Miracle)
  7. Nucleotides (Nucleophile, Lumi eyes)

PROFHILO® H + L treatment

Profhilo is an innovative treatment that has revolutionized the aesthetic market. It is a preparation composed of stabilized hybrid systems of hyaluronic acid. Contrary to standard fillers, it does not contain any cross-linking agents, and the concentration of hyaluronic acid in it is the highest available in the world and amounts to as much as 64 mg.

Treatment time

30 min.

No. of sessions

2-3

Recovery time

1-2 days

Price

250 €

Treatment time

30 min.

No. of sessions

2-3

Recovery time

1-2 days

Price

250 €

What is unique about PROFHILO?

  • It brings very natural visual effects both at rest and during facial movements
  • The procedure takes only 5-10 minutes
  • During the procedure, only 5 punctures per side are made
  • It is thermally stabilized (patented technology that allows the exclusion of emulsifying agents and chemical cross-linking agents such as BDDE, which may cause allergies)
  • It has solid clinical studies that prove its effectiveness
  • It bio-models the skin of the face, enabling the recovery of a beautiful face oval
  • Research has shown that it generates much less inflammation compared to fillers, while stimulating the production of elastin and collagen much more intensively.
  • It combines biovolumetric and stimulating effects

Profhilo is called “the molecule of youth” by the producer for a reason. Its action is comparable to the action of a thousand tiny springs operating inside the skin. It has unique rejuvenating and strengthening properties for the skin, for which it was awarded the gold AMEC AWARD in Paris in 2015.

Profhilo treatment:

  • triggers the production of elastin and collagen types I, II, IV, VII
  • slims facial features
  • rejuvenates the skin
  • causes a biovolumetric effect
  • smoothes wrinkles
  • gives the skin elasticity
  • restores the lost face profile
  • prevents skin sagging
  • increases skin tension

What areas can this treatment be applied to?

  • face
  • neck
  • neckline
  • shoulders
  • hands
  • knees
  • feet.

How many Profhilo series should be performed?

As a standard, the manufacturer recommends two series of treatments with a 30-day interval, and for people with poor skin condition, an additional third treatment 2 months after the last one.

The effects usually last 1-1.5 years. To maintain the effect, 1-2 reminder treatments can be performed within a year.

What is the procedure of the treatment?

The procedure involves the BAP method which was specifically developed and dedicated to Profhilo. This, in turn, ensures the safety and effectiveness of the treatment. First, puncture sites are marked and disinfected. Then, the preparation is administered by injecting it in 5 points on each side, with a total of 10 points using a specially developed technique.

The entire procedure takes approximately 5-15 minutes.

What are stabilized hybrid complexes and how do they work?

Profhilo stabilized hybrid complexes are a combination of:

  • 32 mg of high molecular weight hyaluronic acid (H-HA) – the main component of the skin scaffold and the density of the extracellular matrix,
  • 32 mg of low molecular weight hyaluronic acid (L-HA) – responsible for the initiation of repair processes in the skin.

Contraindications to the Profhilo procedure

  • pregnancy and lactation period
  • hypersensitivity to hyaluronic acid
  • cancers
  • taking medications that change blood clotting
  • active skin infections (e.g. herpes)

Profhilo®
Price

Face 250
Neck 250

The arms

250
Hands 250

Two areas

480

Linerase
treatment

Collagen is a very important protein that occurs in various forms in almost all organs of animal organisms. Its production takes place, among others, in fibroblasts. Collagen present in the skin is fibrillar (fibrous) in nature and acts as a support in it. Unfortunately, after the age of 25, the collagen balance is disturbed and more fibers degrade than form. As a result of increasing collagen losses, the skin collapses, which results in wrinkles.

Linerase is a three-stage rejuvenating treatment that replenishes the skin with collagen and stimulates its formation at the same time. The atelocollagen contained in the preparation has a two-way effect: it stimulates fibroblasts to create their own (endogenous) collagen and stimulates the proliferation (multiplication) of new fibroblasts.

It is perfect as a treatment for acne-prone skin and as an anti-aging treatment. In 2016, it was awarded a prestigious award – it was chosen the “Pearl of Aesthetic Dermatology” in the category of “the best preparation for tissue stimulation”.

Treatment time

45-60 min.

No. of sessions

2-4

Recovery time

2-5 days

Price

250 €

Treatment time

45-60 min.

No. of sessions

2-4

Recovery time

2-5 days

Price

250 €

How does Atelocollagen Linerase work?

  • Regenerates and rebuilds skin defects
  • Reduces scars, stretch marks and fine wrinkles
  • Increases skin density
  • Improves the elasticity and elasticity of the skin
  • Prevents laxity
  • Prevents the aging process

Indications for the use of Linerase therapy

  • Acne scars
  • The aging processes of the skin
  • Loss of skin density and elasticity
  • Stretch marks and atrophic scars
  • Hand skin in poor condition
  • Anti-aging prophylaxis after the age of 25

The course and mechanism of the procedure

The first stage of the treatment is to apply a special peel-off mask, which prepares the skin for the next stages. The retinol present in it modulates the production of keranocytes; vitamin C has an antioxidant effect; polypeptides release growth factors; glycolic and citric acids increase the availability of active substances. Despite the presence of AHA acids, the peel-off Linerase mask does not exfoliate the skin. The perparation also includes moisturizing hyaluronic acid and collagen.

During the second stage, the preparation with atelocollagen is injected in 3-4 selected areas (e.g. face, neck, cleavage, and hands). It is type I collagen, most commonly found in the human body. The atelocollagen contained in Linerase stimulates the production of its own collagen and new fibroblasts, thus playing an important role in ensuring the skin’s youthful appearance.

The third step is to put on a soothing mask and massage.

All three stages are performed during one visit to the clinic.

How many treatments should be performed?

The manufacturer recommends that the treatment consists of 2-4 sessions at 2-3 weeks’ intervals. Then, in order to maintain the effects, use a reminder treatment every 3 months or repeat the full treatment after 6-12 months.

The obtained effects last up to 12 months.

Contraindications:

  • pregnancy and lactation period
  • high susceptibility to allergies
  • autoimmune diseases
  • Cancer
  • active skin infection in the treatment area
  • taking medications that change blood clotting
  • the tendency to develop keloids

Atelokolagen Linerase, compared to the previously used types of collagen, is a very safe, biocompatible and non-immunogenic preparation (thanks to thorough cleansing), which means that it does not require a double skin test before the treatment.

Linerase atelocollagen
Price

Face, neck and cleavage 250
Face, neck, hands 250

Sunekos®
treatment

Sunekos is an innovative combination of hyaluronic acid and amino acids. Using this unique formula ensures the complement of all three components of a youthful-looking skin:

  • hyaluronic acid,
  • collagen,
  • elastin.

Their balance provides the skin with firmness, hydration and elasticity.
Its effectiveness is supported by scientific research.

There are two types of Sunekos:

  1. Sunekos 200 for younger skin with less signs of aging,
  2. Sunekos 1200 for older skin with more visible signs of aging (usually after the age of 40).

Treatment time

30-60 min.

No. of sessions

3-4

Recovery time

2-5 days

Price

from 250 €

Treatment time

30-60 min.

No. of sessions

3-4

Recovery time

2-5 days

Price

from 250 €

The effects of the treatment:

  • long-lasting hydration of both deep and superficial layers of the skin
  • reduction of shadows under the eyes
  • natural volumetric effect
  • reduction of mimic wrinkles
  • greater skin elasticity
  • radiant skin
  • prevention of the first wrinkles
  • smoothing out scars and stretch marks

Indications for the Sunekos treatment:

  • loss of skin firmness and elasticity
  • signs of skin aging – both fine and deep wrinkles
  • photoaging
  • skin dehydration
  • acne scars
  • stretch marks

The course of the treatment:

After preparing the formula, the treatment area is cleaned and disinfected.
The preparation is then administered using one of the three techniques: microbolus, IFT or cannula. The method of administration depends on the condition of the skin and may differ from one treatment session to the next.

Depending on the technique, the skin may be anesthetized with a special ointment before the procedure.

It usually lasts 30-60 minutes.

How many series of treatments are needed? What does the Sunekos protocol look like?

An appropriate treatment protocol is selected depending on the condition of the skin.

  • For younger skin, the protocol of choice is to use 3-4 Sunekos 200 sessions at 7-10 days’ intervals.
  • Older skin requires the use of Sunekos 1200, and then after 2 days Sunekos 200. The next 3 treatments are performed with a milder preparation every 7-10 days.

After 4 months, the manufacturer recommends 2 reminding treatments. The protocols and booster treatments are modified depending on the condition of the skin and the use of other aesthetic medicine treatments.

How does Sunekos work?

Sunekos stimulates the skin’s biogenic process. It stimulates fibroblasts to produce collagen and elastin. It includes:

  • Glycine, L-proline, L-lysine, which are collagen amino acids
  • L- alanine, L- valine- elastin amino acids
  • L-leucine-prosynetic AA
  • Hyaluronic acid – the main component of connective tissue

The innovative formula allows the homeostasis of the ECM extracellular matrix to be maintained in the skin, thus restoring its youthful appearance.

When are the effects visible?

Immediately after the treatment, a delicate and very natural volumetric effect is visible.

Smoothing wrinkles, brightening the skin and making it firmer can already be seen on the 10th day after the treatment, and the final effects last up to six months.

Sunekos®
Price

Sunekos 200 240
Sunekos 1200 250

Sunekos body 10 ml

350

Jalupro®
treatment

Another, very effective preparation consisting of amino acids and high molecular weight hyaluronic acid is Jalup, the winner of the “Pearl of Aesthetic Dermatology”.

It is a preparation rich in glycine, L-proline and L-lysine, which constitute as much as 70% of the collagen structure. It is a treatment recommended especially after invasive treatments, when the skin needs special regeneration.

The manufacturer recommends three series of Jalupro every 30 days.

The treatment can be used on:

  • face
  • neck
  • neckline
  • hands
  • knees
  • elbows
  • and all parts of the body that require skin regeneration.

Contraindications to Sunekos and Jalupro treatments

  • pregnancy and breastfeeding
  • autoimmune diseases
  • tendency to keloids
  • skin inflammation
  • taking medications that change blood clotting
  • Cancer
  • allergy
  • unregulated diabetes

Xela
Rederm

Redermalization

Redermalization is an innovative method of preventing and counteracting the process of aging of the skin. It is the only method that directly affects the metabolic processes in the skin.

Treatment time

40-60 min.

No. of sessions

3

Recovery time

3-6 days

Price

from 150 €

Treatment time

40-60 min.

No. of sessions

3

Recovery time

3-6 days

Price

from 150 €

The effects of the Xela Rederm treatment

  • reducing the depth of wrinkles
  • reduction or removal of discoloration
  • improvement of skin texture
  • lifting effect
  • increasing skin elasticity and elasticity
  • skin nourishment
  • restoration of the proper skin structure
  • increases the level of skin hydration

There are three variants of the Xela Rederm formula:

  • 1.1%
  • 1.8%
  • 2.2%

The choice of the variant depends on the condition of the skin and is individually adapted to the client, depending on the indications.

Indications:

  • “tired face” effect
  • correction of the first symptoms of aging (appearance of the first wrinkles, change of skin color, changes in the face contour, visualization of the nasolabial fold)
  • correction of severe signs of aging (atony, atrophy)
  • gravitational ptosis (age-related ptosis)
  • medium and deep wrinkles and furrows
  • acne changes
  • hyperpigmentation
  • thin skin
  • oily or combination skin
  • preparation for chemical peels and regeneration after their application
  • preparation and regeneration after other aesthetic medicine treatments
  • dry skin
  • skin damaged by negative environmental factors (sunbeds, smoking, pollution) and improper care
  • cavities, laxity of the skin on the abdomen, buttocks, legs, arms and other parts of the body
  • damaged hand skin (there is a possibility of a treatment combined with a chemical peeling)

How many series of treatments should be performed?

You should perform 3 treatment sessions at intervals of two weeks.

A booster treatment is recommended after 6-9 months. You can also repeat a series of three treatments.

Typically, the healing period for the face is 72 hours and for the rest of the body (including the neck and décolleté) 5-6 days.

The mechanism of action of Xela Rederm

The Xela Rederm treatment uses biochemical processes taking place in skin cells. After its application, the following effects are observed:

  • improving cellular respiration
  • enhanced ion transport
  • increasing energy production in the Kresy Cycle in skin fibroblasts
  • collagen synthesis
  • elastin synthesis
  • improvement of microcirculation
  • increase in skin cell viability
  • skin cells are less susceptible to damage
  • inhibition of premature cell disintegration processes
  • increasing the delivery of oxygen to tissues

The preparation consists of two active ingredients: sodium succinate and hyaluronic acid.

Redermalization affects three basic mechanisms of skin deterioration and aging:

  1. Thanks to the succinic acid present in the formula, it effectively neutralizes free radicals
  2. Thanks to the hyaluronic acid, it prevents dehydration of the skin and replenishes the HA deficit in the intercellular space
  3. It regulates both physical and chemical processes preventing disturbances in cell metabolism

Contraindications:

  • pregnancy and breastfeeding
  • decompensated diabetes
  • autoimmune diseases
  • cancers
  • tendency to keloids
  • use of drugs that affect blood clotting
  • active infections

Xela Rederm®
Price

XELA REDERM® 1.1% 150
XELA REDERM® 1.8% 180

XELA REDERM® 2.2%

200

Radiesse®
and Crystalys

Calcium Hydroxyapatite – Skinbooster contained in Radiesse® and Crystalys.

The biostimulants in question are fillers based on calcium hydroxyapatite. They stimulate the intense formation of new collagen and elastin. They have the structure of calcium microspheres suspended in a gel carrier. Their administration causes an immediate filling effect. They fulfill their role in volumetric treatments.

The effects of using fillers with Calcium Hydroxyapatite are:

  • improving the volume and contour of the face by immediate filling
  • increasing skin density
  • filling the nasolabial furrows

The effects visible after the treatment are immediate, but not final – they increase over time, which is caused by the intense stimulation of collagen at the site of the injection. The effects of the treatment last up to 2 years

Areas where they can be applied are:

  • puppet lines
  • nasolabial furrows
  • cheeks
  • hands
  • jaw
  • chin

Contraindications to the use of calcium hydroxyapatite bioboosters:

  • pregnancy and lactation
  • hypersensitivity to any component of the preparation
  • skin inflammation
  • active herpes
  • autoimmune diseases
  • different types of cancer
  • presence of foreign bodies in the treatment area (e.g. liquid silicone)

Crystalys®
Price

1.5 ml 270

Ellanse™

Ellanse is a new generation biostimulating filler that provides natural effects both at rest and during facial movements, made possible by its complete integrity with the extracellular matrix. The filling effect occurs immediately after administering the formula. After about a month, a partial loss of volume can be observed, and in the following months there is a gradual synthesis of collagen – the filled places regain their volume from the period immediately after the treatment. The quality of the skin is also improved.

Treatment time

30-60 min.

No. of sessions

1

Recovery time

2-3 days

Price

from 220 €

Treatment time

30-60 min.

No. of sessions

1

Recovery time

2-3 days

Price

from 220 €

Ellanse owes its uniqueness to the composition of two ingredients:

  • carboxycellulose (makes up 70% and causes an immediate filling effect)
  • polycaprolactone (PCL, makes up 30% and is responsible for the gradual production and build-up of collagen type I at the injection sites)

It does not cause severe inflammation, nor are allergic reactions and granulomas observed after its application. It is a completely biodegradable biostimulator.

Ellanse effects

  • improvement of skin quality
  • shallow furrows and wrinkles
  • face modeling
  • recovery of the face oval
  • reduction of falling corners
  • rejuvenation and increase of skin density
  • natural volumetry effect,

Indications of the Ellanse

  • deepened marionette furrows
  • deepened nasolabial folds
  • loss of face oval
  • loss of skin firmness
  • lowered mouth corners
  • signs of aging
  • thin skin
  • a progressive loss of adipose tissue and bone which cause a change to the facial features

What is the Ellanse biostimulation mechanism?

It is the polycaprolactone that is responsible for the biostimulating properties of Ellanse. Once deposited in the skin, its microspores decapsulate and begin to form a specific scaffold, where mainly type I collagen fibers are deposited.

Durability of effects

The durability of the effects depends on the preparation used. Ellanse S lasts a year in the skin, Ellanse M – 2 years, Ellanse L – 3 years, and Ellanse E – 4 years.

Ellanse®
Price

S 220
M 250
L 300

Nucleofill

Fast lifting at the cellular level

Nucleofill is an innovative product that tightens, firms and moisturizes the skin, ensuring its rejuvenation and beautification. Its active ingredient is a polynucleotide gel, whose action is based on the following mechanisms:

  • antioxidant effect
  • stimulation of fibroblasts
  • tissue hydration

Nucleofill is a product consisting of long polymer chains of naturally derived polynucleotides. It is sterile, absorbable and free from fever-causing substances (pyrogen-free).

Treatment time

10-40 min.

No. of sessions

4

Recovery time

2-3 days

Price

from 220 €

Treatment time

10-40 min.

No. of sessions

4

Recovery time

2-3 days

Price

from 220 €

Indications:

  • signs of aging
  • damage to the skin structure related to exposure to UV radiation,
  • environmental pollution and smoking
  • formation of wrinkles
  • dehydrated skin

What is unique about the Nucleofill treatment?

  • has a multi-track effect
  • is composed of polynucleotides
  • counteracts photoaging
  • rejuvenates the skin
  • shows antioxidant properties
  • suitable for all skin types
  • provides a clear rejuvenation without intervening on the facial features

Lifting action

Under the influence of the Nucleofill components, the receptors on fibroblasts are stimulated, which in turn cause the formation of new collagen and elastin. As a result, the skin becomes denser, more elastic and firm.

Moisturizing action

Under the influence of the Nucleofill formula, water is bound by the hydrophilic groups of nucleotides. This leads to deep tissue hydration.

Antioxidant (antioxidant) effect of Nuclofill

The polymeric molecules of the Nucleofill formula have the ability to bind free radicals into aromatic rings in nitrogen bases. This action is called antioxidant and helps to restore the skin’s balance. The neutralization of free radicals delays the skin aging process caused by their presence.

How many Nucleofill series should be made?

To ensure the best results, 4 series of treatments performed at intervals of 15-30 days are necessary.

What are free radicals?

Free radicals are unpaired atoms which are formed as a result of various chemical reactions. Due to the presence of one free electron, they are chemically very reactive.

Free radicals try to recover the missing electron by taking it over from other molecules. They contribute to DNA degradation and are considered a cause of aging.

Free radicals present in the skin oxidize, inter alia, collagen and elastin proteins, contributing to the loss of elasticity and the formation of wrinkles. Oxidation of epidermal fats disrupts the skin’s protective barrier, which leads to its sensitization and drying. The presence of free radicals also reduces the skin’s regenerative capacity.

Free radicals wreak havoc not only on the skin, but also throughout the body. They contribute to the emergence of many serious diseases. That is why it is so important to avoid the behaviors that cause them:

  • smoking a cigarette
  • drinking alcohol
  • breathing polluted air
  • intensive sunbathing
  • consuming smoked, grilled and fried foods
  • stressful lifestyle

What is the course of the procedure?

After disinfecting the epidermis, with a needle or cannula, the formula is introduced into the deep layers of the skin.

The type of formula used and the application technique are selected individually.

An anesthetic cream is used before using some of the administration techniques involving more punctures.

Contraindications:

  • pregnancy and lactation
  • cancers of various kinds
  • epilepsy
  • autoimmune diseases (past and present)
  • diabetes
  • severe allergy
  • persistent inflammation
  • hypersensitivity to the ingredients of the preparation
  • circulatory diseases
  • anticoagulants
  • active herpes
  • infection
  • age under 18
  • swelling or redness in the treatment area
  • fever

Nucleofill
Price

Strong 1.5 ml 240
Medium 1.5 ml 220